Distribution of <i>KRAS</i><sup>G12C</sup> Somatic Mutations across Race, Sex, and Cancer Type
نویسندگان
چکیده
KRASG12C Somatic Mutations in Various Cancers A survey of more than 32,000 cancers the GENIE registry detected differences distribution mutations various cancer types and i...
منابع مشابه
Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations
Identifying driver mutations and their functional consequences is critical to our understanding of cancer. Towards this goal, and because domains are the functional units of a protein, we explored the protein domain-level landscape of cancer-type-specific somatic mutations. Specifically, we systematically examined tumor genomes from 21 cancer types to identify domains with high mutational densi...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Disparities in cancer outcomes across age, sex, and race/ethnicity among patients with pancreatic cancer
Age, sex, and racial/ethnic disparities exist, but are understudied in pancreatic adenocarcinoma (PDAC). We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to determine whether survival and treatment disparities persist after adjusting for demographic and clinical characteristics. Our study included PDAC patients diagnosed between 1992 and 2011. We used Cox ...
متن کاملSomatic mutations in cancer development
The transformation of a normal cell into a cancer cell takes place through a sequence of a small number of discrete genetic events, somatic mutations: thus, cancer can be regarded properly as a genetic disease of somatic cells. The analogy between evolution of organisms and evolution of cell populations is compelling: in both cases what drives change is mutation, but it is Darwinian selection t...
متن کاملSomatic mutations in aging, cancer and neurodegeneration.
The somatic mutation theory of aging posits that the accumulation of mutations in the genetic material of somatic cells as a function of time results in a decrease in cellular function. In particular, the accumulation of random mutations may inactivate genes that are important for the functioning of the somatic cells of various organ systems of the adult, result in a decrease in organ function....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The New England Journal of Medicine
سال: 2021
ISSN: ['0028-4793', '1533-4406']
DOI: https://doi.org/10.1056/nejmc2030638